Relevance of oral experimental challenge with classical scrapie in sheep
نویسندگان
چکیده
منابع مشابه
Experimental Oral Transmission of Atypical Scrapie to Sheep
To investigate the possibility of oral transmission of atypical scrapie in sheep and determine the distribution of infectivity in the animals' peripheral tissues, we challenged neonatal lambs orally with atypical scrapie; they were then killed at 12 or 24 months. Screening test results were negative for disease-specific prion protein in all but 2 recipients; they had positive results for examin...
متن کاملEvidence of in utero transmission of classical scrapie in sheep.
Classical scrapie is one of the transmissible spongiform encephalopathies (TSEs), a group of fatal infectious diseases that affect the central nervous system (CNS). Classical scrapie can transmit laterally from ewe to lamb perinatally or between adult animals. Here we report detection of infectivity in tissues of an unborn fetus, providing evidence that in utero transmission of classical scrapi...
متن کاملObjects in Contact with Classical Scrapie Sheep Act as a Reservoir for Scrapie Transmission
Classical scrapie is an environmentally transmissible prion disease of sheep and goats. Prions can persist and remain potentially infectious in the environment for many years and thus pose a risk of infecting animals after re-stocking. In vitro studies using serial protein misfolding cyclic amplification (sPMCA) have suggested that objects on a scrapie-affected sheep farm could contribute to di...
متن کاملExperimental transmission of atypical scrapie to sheep
BACKGROUND Active surveillance for transmissible spongiform encephalopathies in small ruminants has been an EU regulatory requirement since 2002. A number of European countries have subsequently reported cases of atypical scrapie, similar to previously published cases from Norway, which have pathological and molecular features distinct from classical scrapie. Most cases have occurred singly in ...
متن کاملRole of palatine tonsils as a prion entry site in classical and atypical experimental sheep scrapie.
Atypical and classical scrapie-infected sheep brain tissue was monolaterally injected into the tonsils of lambs to investigate their role as a prion entry point. We first detected classical PrP(Sc) within the inoculated tonsil and in the ipsilateral retropharyngeal lymph node at 3 months postinoculation (p.i.). At 7 months p.i., PrP(Sc) colonized other lymphoid tissues bilaterally, including il...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2010
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.021311-0